https://adrjournalshouse.com/index.php/nanoscience-nanotechnology Journal of Advanced Research in Nano science and Nano Technology Advanced Research Publications en-US Journal of Advanced Research in Nanoscience and Nanotechnology <p>We, the undersigned, give an undertaking to the following effect with regard to our article entitled<br>“_______________________________________________________________________________________________________________________________________________________________________________<br>________________________________________________________________________________” submitted for publication in (Journal title)________________________________________________ _______________________________________________________Vol.________, Year _________:-</p> <p>1. The article mentioned above has not been published or submitted to or accepted for publication in any form, in any other journal.</p> <p>2. We also vouchsafe that the authorship of this article will not be contested by anyone whose name(s) is/are not listed by us here.</p> <p>3. I/We declare that I/We contributed significantly towards the research study i.e., (a) conception, design and/or analysis and interpretation of data and to (b) drafting the article or revising it critically for important intellectual content and on (c) final approval of the version to be published.</p> <p>4. I/We hereby acknowledge ADRs conflict of interest policy requirement to scrupulously avoid direct and indirect conflicts of interest and, accordingly, hereby agree to promptly inform the editor or editor's designee of any business, commercial, or other proprietary support, relationships, or interests that I/We may have which relate directly or indirectly to the subject of the work.</p> <p>5. I/We also agree to the authorship of the article in the following sequence:-</p> <p>Authors' Names (in sequence) Signature of Authors<br>1. _____________________________________ _____________________________________<br>2. _____________________________________ _____________________________________<br>3. _____________________________________ _____________________________________<br>4. _____________________________________ _____________________________________<br>5. _____________________________________ _____________________________________<br>6. _____________________________________ _____________________________________<br>7. _____________________________________ _____________________________________<br>8. _____________________________________ _____________________________________</p> <p>Important</p> <p>(I). All the authors are required to sign independently in this form in the sequence given above. In case an author has left the institution/ country and whose whereabouts are not known, the senior author may sign on his/ her behalf taking the responsibility.</p> <p>(ii). No addition/ deletion/ or any change in the sequence of the authorship will be permissible at a later stage, without valid reasons and permission of the Editor.</p> <p>(iii). If the authorship is contested at any stage, the article will be either returned or will not be<br>processed for publication till the issue is solved.</p> https://adrjournalshouse.com/index.php/nanoscience-nanotechnology/article/view/2509 <p>Therapeutic peptides have emerged as promising candidates for treating a wide range of diseases, including metabolic disorders, cancers, and autoimmune conditions, owing to their high specificity, potency, and low toxicity. However, their oral administration remains a major challenge because of their poor bioavailability, primarily due to gastrointestinal (GI) enzymatic degradation, low intestinal epithelial permeability, and first-pass metabolism. Conventional delivery systems often fail to overcome these barriers, limiting the clinical application of oral peptide formulations in humans. In recent years, permeation enhancer and nanocarrier hybrid systems have gained significant attention as an innovative strategy to overcome these limitations. By integrating the advantages of permeation enhancers (which modulate intestinal barrier function) and nanocarriers (which protect peptides from degradation and improve targeted delivery), these hybrid systems can synergistically enhance the oral bioavailability of therapeutic peptides. This review summarises the key challenges in oral peptide delivery, elaborates on the mechanisms of action of permeation enhancers and nanocarriers, and highlights the design, optimisation, and in vitro and in vivo performance of hybrid systems. In addition, current advancements, clinical translation prospects, and future directions in this field are discussed to provide insights into the development of effective oral peptide formulations.</p> Abdul Fazil Udaya Kumar Nagapatla Copyright (c) 2026 Journal of Advanced Research in Nanoscience and Nanotechnology http://creativecommons.org/licenses/by-nc/4.0 2026-01-31 2026-01-31 8 1 1 6